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GES 103University of IbadanSep 26, 2026

8 (2). EQUILIBRIA BUFFERS

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6 Concept Stages

Practice Exam

73+ Questions

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Executive Topic Summary

Master the foundational principles of chemical equilibrium, ionic dissociation, acid–base theory, and buffer systems—then apply every concept directly to real pharmaceutical scenarios including drug absorption, formulation stability, clinical overdose management, and injectable safety. This lecture transforms abstract equilibrium theory into the practical toolkit that every pharmacist uses daily.

High-Yield Exam Takeaways

  • Chemical Equilibrium Foundations: The Dynamic Balance
  • Ionic Equilibrium in Solution: Electrolytes, Dissociation, and Solubility
  • Acid–Base Equilibria: The Henderson–Hasselbalch Equation and Drug Ionization
  • Buffer Solutions: Resisting pH Change in Pharmaceutical Formulations
  • Integrated Pharmaceutical Scenarios: Connecting Theory to Practice
  • Summary and Exam Mastery: The Four Pillars of GES 103

Study Tree Preview (Bite-Sized Concepts)

Previewing 3 stages

1Chemical Equilibrium Foundations: The Dynamic Balance

4 Micro-Bites
Understanding Chemical Equilibrium: A System in Constant Motion:Here's the mind-bending truth: at chemical equilibrium, the reaction never actually stops. Forward and reverse reactions keep happening constantly—but at exactly the same rate. Ima...
The Equilibrium Constant (Keq): Quantifying the Balance:Now we need a number to describe where that balance point sits. Enter the <term def="a fixed number at a given temperature that describes the ratio of product concentrations to rea...

2Ionic Equilibrium in Solution: Electrolytes, Dissociation, and Solubility

5 Micro-Bites
Strong vs. Weak Electrolytes: The Ionization Divide:An <term def="a substance that conducts electricity when dissolved in water because it breaks apart into ions">electrolyte</term> is any substance that conducts electricity in solu...
Dissociation Constants (Ka, Kb): Quantifying Acid and Base Strength:For a weak acid HA dissolving in water, we write the equilibrium: $$HA \rightleftharpoons H^+ + A^-$$ The <term def="the equilibrium constant that describes how readily a weak ac...

3Acid–Base Equilibria: The Henderson–Hasselbalch Equation and Drug Ionization

5 Micro-Bites
Brønsted–Lowry Acid–Base Theory: Proton Donors and Acceptors:The modern definition of acids and bases is beautifully simple. According to <term def="a theory defining acids as proton (H⁺) donors and bases as proton (H⁺) acceptors">Brønsted–L...
The Henderson–Hasselbalch Equation: The Single Most Important Equation in Pharmacy:This is it—the equation that predicts drug behavior in the body more directly than any other. For a weak acid and its conjugate base: $$pH = pK_a + \log_{10} \frac{[A^-]}{[HA]}$$ ...

Sample Practice Questions (Active Recall)

Showing 3 of 73+

Q1.Which of the following best describes the state of a chemical system at equilibrium?

AThe concentrations of reactants and products are equal.
BThe forward and reverse reactions occur at equal rates, but the reactions never stop.
CThe forward and reverse reactions have stopped occurring.
DThe system is static with no molecular movement.

Q2.What does a large equilibrium constant (Keq) indicate about a reaction?

AThe reaction is endothermic.
BThe reaction favors reactants at equilibrium.
CThe reaction favors products at equilibrium.
DThe reaction is irreversible.

Q3.According to Le Chatelier's Principle, how will a system at equilibrium respond if more reactant is added?

AIt will shift toward products only if the reaction is exothermic.
BIt will shift toward reactants to consume the added reactant.
CIt will shift toward products to consume the added reactant.
DIt will remain unchanged as Keq is constant.

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