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BCH 307David Umahi Federal University of Health SciencesOct 18, 2026

Genome Organization

Structure

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20+ Questions

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Executive Topic Summary

High-yield cheatsheet and core concepts for BCH 307.

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  • High-Yield Cheatsheet for BCH 307
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Sample Practice Questions (Active Recall)

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Q1.Which of the following best explains why the C-value paradox exists in higher eukaryotes?

AGenome size does not correlate with organismal complexity due to variable amounts of non-coding and repetitive DNA
BMitochondrial DNA compensates for reduced nuclear genome size
CProtein-coding gene number increases exponentially with organismal complexity
DIntrons are absent in higher eukaryotes, reducing DNA content

Q2.What is the consequence of histone H1 binding to chromatin?

AIt promotes transcription by loosening nucleosome structure
BIt stabilizes higher-order chromatin structures by binding to linker DNA between nucleosomes
CIt prevents DNA methylation at CpG islands
DIt replaces histone H4 in the octamer core

Q3.How does Z-DNA differ from B-DNA in terms of helical structure?

AZ-DNA has parallel strands running in the same direction
BZ-DNA is right-handed with 10.5 base pairs per turn
CZ-DNA lacks major and minor grooves entirely
DZ-DNA is left-handed with a zigzag backbone and 12 base pairs per turn

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